IFNA1 and cardiovascular disorder: We used gene expression profiles from two previously published studies: (1) Fairfax et al. [12] (FF), in which CD14+ human monocytes were profiled with two inflammatory stimuli: naïve (CD14), and in response to either interferon-γ (IFN), or lipopolysaccharide at 2 hours (LPS2), and 24 hours (LPS24); and (2) primary human monocytes and macrophages from the Cardiogenics Consortium (CG) [30], which includes subjects from a Cardiovascular disease cohort (Fig 1).