Another Alzheimer’s disease-associated variant rs9331896-C (MAF = 0.41, PGWAS = 3x10-25) located on chromosome 8p21 within intron 2 of the CLU gene is associated with the individual scores of a component consisting of 38 genes with non-zero scores (P = 1.32x10-4; FDR < 0.15) (Fig 6A and 6B). Here, CLU is linked to early-onset autosomal dominant Alzheimer disease.