More recently, Salih et al. [33] identified a number of interferon signaling genes to be in co-expression network that is expressed in amyloid-responsive mouse microglia, including Oas and Ifit family members, and transcription factors such as Irf7 and Stat. The authors further found that Alzheimer’s disease loci colocalize with cis-eQTLs targeting OAS1 in interferon-γ stimulated iPSC-derived macrophages. The gene discussed is OAS1; the disease is early-onset autosomal dominant Alzheimer disease.