We also observed that the top combination hits selected by SynToxProfiler are highly overlapping between different synergy models; for instance, 9 and 8 of the top-10 combinations identified based on the STE score using ZIP synergy model are actually the same when using Bliss and HSA models in T-PLL and anti-Ebola screening, respectively (S2 and S3 Tables). This evidence concerns the gene ALB and Ebola hemorrhagic fever.