We screened a list of 47 cancer driver mutation hotspots, determined based on recurrence in cohorts where we could access mutation calls in an unbiased manner (see Methods), in a total of 7,345 colorectal cancer samples including 47 POLE mutants (16 P286R, 15 V411L and 16 Other-Exo mutants with Sig10) and 7,298 POLE wild-type samples, to investigate if any hotspots are enriched in specific POLE mutants (S2 Table). Here, POLE is linked to cancer.