TP53 and colorectal cancer: This suggests that this enrichment is specific to colorectal cancer and may reflect the higher apparent positive selection for TP53 mutations in colorectal cancer compared with endometrial cancers in general with 57% (4,677/7,345) TP53 mutants in colorectal cancer versus 48% (974/2,045) TP53 mutants in endometrial cancer (P < 0.001, Fisher's exact test).