Based on the UBE2M expression in HCC cell lines, we adopted PLC/PRF/5 and MHCC-97L cells with relative higher UBE2M expression for loss-of-function studies in vitro, while SMMC-7721 and BEL-7402 cells with relative lower UBE2M expression for gain-of-function assays in vitro (Supplementary Figure 2). This evidence concerns the gene UBE2M and hepatocellular carcinoma.