UBE2M and hepatocellular carcinoma: We found that the UBE2M expression in HCC tissues was significantly higher than that in matched tumor-free tissues using a pair-wise comparison analysis (7.28 ± 3.66 vs. 4.02 ± 3.56; Figure 1B, 1C and Supplementary Figure 1; P < 0.001), which is consistent with the data in The Cancer Genome Atlas (TCGA; Figure 1D, P < 0.0001).