Meanwhile, we also defined 30 frequently mutated genes in Chinese bladder cancer samples from ICGC cohort, and the five most frequently mutated genes were MUC4 (58%), TP53 (24%), FMN2 (23%), PIK3CA (23%), and KDM6A (21%) (Figure 1B). This evidence concerns the gene MUC4 and urinary bladder carcinoma.