In this regard, in malignant melanoma it has been shown that altered expression of the long non-coding RNA (lncRNA) SAMMSON sequesters CDKN2AIP in an aberrant cytoplasmic RNA–protein complex, which promotes XRN2 localisation to the nucleoli, stimulating rRNA biogenesis, protein synthesis, and tumour cell growth [30]. Here, XRN2 is linked to neoplasm.