His blood cell counts, hematocrit, hepatic and renal function, cytokeratin-19 fragment, carcinoembryonic antigen, squamous cell carcinoma, and carbohydrate antigen 125 were all in normal range, except significantly elevated serum neuron-specific enolase (NSE) of 133.0 ng/ml (normal range, 0–16.3 ng/ml). The gene discussed is ENO2; the disease is squamous cell carcinoma.