Case Report of acute myeloid leukemia with “WT1, ATRX, CEBPA, CSMD1, IKZF1, and LRP1B mutation and translocation between chromosome 1 and 19” developing from Philadelphia-negative chronic myeloid leukemia after TKI therapy. The gene discussed is IKZF1; the disease is chronic myelogenous leukemia, BCR-ABL1 positive.