As summarized by Duyff et al, the mean TSH level was 53 mU/L in patients with hypothyroidism-induced myopathy.[5] In particular, 1 patient who had received total thyroidectomy developed rhabdomyolysis only 2 weeks after the discontinuation of levo-triiodothyronine (L-T3) replacement in preparation for thyroid remnant ablation, suggesting that the rapid reduction of thyroid hormone cause more muscular damage than slowly progressed hypothyroidism.[2]. This evidence concerns the gene TG and hypothyroidism.