TNF and chordoma: Recently, a study has shown that the proliferation and invasiveness of the sacral chordoma cell line after TNF-α treatment are enhanced, and a series of experiments have proven that TNF-α can be used as a prognostic indicator of chordoma develpment and inflammatory chordoma promotion.[9] This may be related to the genetic pathways involved in the development of chordoma activated by TNF-α.