The first meta-analysis included five randomized controlled trials (RCTs) indicated that PDE5-Is can significantly improve the IPSS and IIEF compared with placebo though failed to find significant improvement in the Qmax.[2] Subsequently, several meta-analyses have defined the efficacy and safety of PDE5-Is drugs alone or in combination with tamsulosin in LUTS/BPH with or without ED.[3,4] The combination of 2 types of drugs has been found more effective and safe in alleviating LUTS than using each separately. Here, PDE5A is linked to benign prostatic hyperplasia.