Recently studies[31] reported that SOX9 can interact with and regulate AR expression in PCa cells, which express high levels of AR in PCa cells indicates that SOX9-regulated genes may similarly play critical roles in supporting PCa growth.[32] SOX9 also acts as a transcription factor in the development of prostate epithelia and its overexpression evidently plays a role in PCa tumorigenesis[33,34] by the Wnt/h-catenin pathway, which has been implicated in the initiation and progression of many types of cancer. Here, SOX9 is linked to cancer.