TWIST1 and Saethre-Chotzen syndrome: Saethre-Chotzen syndrome (OMIM # 101400) is caused by TWIST1 mutations, and it is an autosomal dominant craniosynostosis syndrome with uni- or bi-lateral coronal synostosis and mild limb deformities (Musculoskeletal Diseases) (Sharma et al., 2013; Murphy et al., 2018).