Importantly, under fixed parameter values for the infection incubation rate (σ) and infection-induced mortality rate (α), models were unable to reproduce the longer-term infectious time series captured in data from rVSV-EBOV infections on PaKiT01 cell lines without incorporation of cell births, an assumption adopted in previous modeling representations of IFN-mediated viral dynamics in tissue culture (Howat et al., 2006). This evidence concerns the gene IFNA1 and infection.