CDC6 and cancer: So far, we can see that; senescence is characteristic of a barrier13, 18, 20, 22 (Fig. 2) and has been shown in pancreatic cancers,35 and Cdc6 has been associated with the induction of senescence.13, 14 Putting all this together, it will therefore be interesting to note the direct implications of Cdc6 on the induction of senescence, the mechanisms facilitating the eventual escape of cells from the senesced state leading to cancer progression, and are there, if any, exploitable pathways to senescence, knowing the Cdc6 status.