For instance, in the context of interactions between genetic and environmental factors, it has been reported that the harmful effects of unhealthy lifestyle (i.e., unhealthy diet, alcohol misuse, smoking, physical inactivity) may be more pronounced among carriers of apolipoprotein E (APOE) ε4 allele, which is the most well-known genetic risk factor of late-onset AD (43). The gene discussed is APOE; the disease is Alzheimer disease.