Several studies have shown the lack of sensitivity, specificity, and poor positive predictive value of CBC and CRP in the evaluation of EOS.34 Abnormal lab values in asymptomatic infants with culture-negative sepsis may lead to unnecessary NICU admission, prolonged antibiotic exposure, and increased length of stay.6 However, both CBC and CRP have an excellent negative predictive value.8 Among CBC indices, the I:T has a high negative predictive value for neonatal infections.35 If I:T is <0.2 at 6 to 12 hours of life, the likelihood of having an infection is very low. The gene discussed is CRP; the disease is infection.