TNF and depressive symptom measurement: Several case reports exist that display a pattern of rapid onset neuropsychiatric symptoms just months after beginning TNF-α inhibitor therapy despite an improvement of the medical condition, which may be indicative of shared pathogenesis.3,4 Remarkably, in each of these cases, additional risk factors for depression and suicide exist, such as a family history or concurrent psychiatric and medical illness, which likely contributed to their susceptibilities.