Both MAM and PSA prevented dextran sulfate sodium (DSS)- and 2,4,6-trinitrobenzenesulfonic acid (TNBS)-induced colitis in murine models, reducing Th1, Th17, and Th2 immune responses, and promoting Treg production of IL-10 and TGF-β (14, 15). This evidence concerns the gene IL10 and colitis.