CCND1 and cancer: The anti-cancer effect of ATO mainly depends on its ability to induce ubiquitin-dependent proteasomal degradation of various oncogenic proteins, including promyelocytic leukemia-retinoic acid receptor-alpha (PML-RARA) in APL, cyclin D1 in mantle cell lymphoma, and nucleophosmin-anaplastic lymphoma kinase (NPM-ALK) in anaplastic large cell lymphoma (Shao et al., 1998; Lo and Kwong, 2014; Piao et al., 2017).