Accordingly, IGF2BP3 is detectable in some premalignant human lesions, including dysplasia in Barrett esophagus (Gadara et al., 2017), pancreatic intraductal neoplasia (Wang et al., 2015), and atypical endometriosis (Vercellini et al., 2013); in addition, many tumor types upregulate IGF2BP3 compared to normal tissue counterparts (Figure 2). This evidence concerns the gene IGF2BP3 and Barrett esophagus.