IGF2BP3 and neoplasm: Compared to the phenotype of IGF2BP3-null cells, IGF2BP3-expressing tumor cells display a marked motility-prone phenotype with an adherent shape, cellular extensions, lamellipodia, frequent cell–cell adhesion contacts (Vikesaa et al., 2006) and an increased capability to form metastases in vivo (Zhao et al., 2017; Mancarella et al., 2018b).