IGF2BP3 and Ewing sarcoma: In addition, inhibitors of bromodomain and extraterminal domain (BET) proteins, such as JQ1 or iBET, have been found to downregulate IGF2BP3 expression and its targets in Ewing sarcoma and B cell acute lymphoblastic leukemia, consequently attenuating tumor growth (Palanichamy et al., 2016; Elagib et al., 2017; Mancarella et al., 2018b).