Chromatin immunoprecipitation (ChIP) assays (Box 1) confirmed the direct binding of the transcription factors Nanog and NF-κB to the IGF2BP3 promoter, thus sustaining its expression in tumor cells and favoring the stemness and migration properties, respectively (Chen et al., 2013; Bhargava et al., 2017). Here, IGF2BP3 is linked to neoplasm.