Furthermore, 5% of thyroid tumors and 25% of pancreatic cancers hold a specific balanced chromosomal translocation between the IGF2BP3 chromosomal locus on 7p15.3 and the actively transcribed THADA locus on 2p21, which results in the strong overexpression of IGF2BP3 (Panebianco et al., 2017). Here, IGF2BP3 is linked to familial pancreatic carcinoma.