Accordingly, IGF2BP3 is detectable in some premalignant human lesions, including dysplasia in Barrett esophagus (Gadara et al., 2017), pancreatic intraductal neoplasia (Wang et al., 2015), and atypical endometriosis (Vercellini et al., 2013); in addition, many tumor types upregulate IGF2BP3 compared to normal tissue counterparts (Figure 2). Here, IGF2BP3 is linked to neoplasm.