It can be speculated that through protection against Let-7 miRNA, IGF2BP3 favors the stability and translation of (1) IGF1R mRNA, thereby affecting the constitutive activation of its intracellular pathway and the in vitro growth of hepatocellular carcinoma or Ewing sarcoma cells (Fawzy et al., 2016; Mancarella et al., 2018a); (2) MYC and CDK6 transcripts, thereby promoting the proliferation of hematopoietic stem and progenitor cells in mice (Palanichamy et al., 2016). This evidence concerns the gene IGF2BP3 and Ewing sarcoma.