The repression of EIF4E-BP2 through the IGF2BP3-mediated recruitment of ribonucleases within RNPs promotes the proliferation of cancer cells (Mizutani et al., 2016); the IGF2BP3-induced destabilization of miR145-5p favors the expression of WNT5B, which activates TAZ, a transcriptional coactivator of Hippo signaling necessary for the function of breast cancer CSCs (Samanta et al., 2018). Here, EIF4EBP2 is linked to breast cancer.