APOE and Cerebral ischemia: These changes in the levels of phosphorylated GSK3β forms presented by us here may fit the reports of increased GSK3β (S9) level (time dependent) under neurotoxic conditions, such as amyloid-beta and apoE4 milieu [as well as experimental diabetes, traumatic brain injury and cerebral ischemia, and some changes in GSK3β (Y216) levels (Planel et al., 2007; Zhao et al., 2012; Morales-Corraliza et al., 2016; Kisoh et al., 2017; van der Harg et al., 2017)].