TYMP and cancer: In the second mechanism, which has been recently studied by Vara et al. (2018), the 2dDR-1-phosphate (2dDRP) is produced either internally by cells which express TP such as macrophages, platelets and cancer cells and then secrete this extracellularly, or TP may be released from injured cells to act on enzymatic degradation of thymidine and generation of 2dDR extracellularly.