In CRC, lncRNA MALAT1 can bind to splicing factor proline and glutamine rich (SFPQ) (also termed PSF [PTB-associated splicing factor]) and enhance the release of polypyrimidine tract cooperating with protein 2 (PTBP2) from the SFPQ/PTBP2 complex (56). The gene discussed is PTBP2; the disease is colorectal carcinoma.