ETV6 and precursor B-cell acute lymphoblastic leukemia: Chromosomal translocation t(12;21)(p13;q22) leads to the ETV6-RUNX1 fusion protein, consisting of the N-terminal non-DNA-binding domain of ETV6 combined with RUNX1, and is the most common alteration in childhood B-ALL (~30%), but it is rarely observed in T-ALL (69).