Braoudaki et al. suggested that CLUS, CERU, FCN3, GELS, APOA1, APOE, APOA4, S10A9, ACTB, CATA, AFAM, and AMBP proteins can be considered as potential prognostic markers for aggressive pediatric B-ALL. The gene discussed is ACTB; the disease is precursor B-cell acute lymphoblastic leukemia.