The rs174549 was in high LD with rs174548 (r2 = 0.98), which was proven to be correlated with lung cancer risk by regulating FADS1 gene expression in liver tissues (β = −0.23, P = 2.20 × 10−7, Supplementary Figure 2F) and plasma levels of polyunsaturated fatty acids (PUFAs) according to our recent study (22). Here, FADS1 is linked to lung cancer.