The importance of GAG decoration on perlecan has been further demonstrated in Hspg2Δ3/Δ3 mice, whereby deletion of exon 3 of the Hspg2 gene removes the GAG attachment sites in Domain I and the mice presented with impaired angiogenesis, delayed wound healing, and retarded tumor growth (153). The gene discussed is HSPG2; the disease is neoplasm.