However, in contrast, Shen et al. (22) demonstrated that tubulointerstitial nephritis antigen-like 1 (TINAGL1), an ECM protein which competitively binds to integrins α5β1, αvβ1, and epidermal growth factor receptor (EGFR), can inhibit fibronectin-mediated FAK/EGFR signaling. The gene discussed is EGFR; the disease is nephritis.