MAP2K1 and cancer: We then checked the role of some important proteins from different biochemical signal transduction pathways: Gsk3α and β-catenin from Wnt/β-catenin signaling; JAK, STAT3, and p53 from JAK-STAT signaling; p38MAPK, MEK1, and SAPK/JNK from MAPK signaling; and AKT, mTOR, LC3, p62, and PI3K from PI3K/AKT/mTOR signaling in three cancer cells.