This outcome suggests that the correlation between MRE11 and TIICs differs among cancers of different tissue origin, and the differential clinical significance of combination between MRE11 and TIICs in the cancers from same organ which have different embryo origin (e.g., RSCC and LSCRC), although we could not detect the specific types of TIICs in the present study. This evidence concerns the gene MRE11 and cancer.