At 1:2 dilution of sMICAhigh sera (n=10), there were 30.8%±10.1% of the MICA-expressing target cells were killed compared with 63.7%±12.2% of the target cells killed in presence of 1: 2 dilution of sMICAlow sera (n=10) from HCC (Fig. 4D); More cells were escaped from killing in presence of sMICAhigh serum than that of sMICAlow serum (t=2.919, P=0.043). This evidence concerns the gene MICA and hepatocellular carcinoma.