Pin1 participates in a variety of processes, including cell proliferation, growth suppressor evasion, genome instability and centrosome amplification, and Pin1 acts on its substrates cyclin D1, AKT, ERα, β-catenin, NF-κB, and c-MYC at the tumour initiation stage in breast cancer [8]. This evidence concerns the gene AKT1 and breast carcinoma.