Along the same lines, Qun Gao (2019) found that DOC induced CD8+ T cell recruitment to the tumor microenvironment by enhancing the secretion of HMGB1 and CXCL11 [38], underlining another view that successful trafficking relies on an appropriate match between the chemokine receptors on T cells and the chemokines secreted by the tumors [39]. The gene discussed is HMGB1; the disease is neoplasm.