In silico analysis of, mt ND1 (3695 AC>A) and mt ND5 (12871 G>A) in CzechII R12 tumor transplants, investigated SNP variant consequence; SNP variant impact; protein position; amino acid changes; and SIFT prediction of the SNP variant impact on amino acid changes which may affect protein function. This evidence concerns the gene MT-ND5 and neoplasm.