CDHR3 (MIM 615610) encodes a transmembrane epithelial protein and was previously identified in GWAS for childhood ear infections (Pickrell et al., 2016) and also for asthma exacerbations in children primarily due to viral respiratory infections (Bønnelykke et al., 2014; Everman et al., 2019). Here, CDHR3 is linked to ear infection.