Changes in the expression of crx have also been implicated in the retinal degeneration of Astyanax and Sinocyclocheilus cavefish (Jeffery, 2009; Meng et al., 2013; Mcgaugh et al., 2014; Yang et al., 2016), and in the present study, we detected the downregulated expression of this gene and associated downstream transcription factors (e.g., gnat2 and nr2e3). This evidence concerns the gene NR2E3 and retinal degeneration.