DNA methylation also plays a promising role in regulation of obesity; this was demonstrated in a study involving administration of Lactobacillus rhamnosus and Bifidobacterium lactis to pregnant women, which resulted in a decrease in the methylation of the FTO and MC4R promoters in the women and their children (Vahamiko et al., 2019). This evidence concerns the gene FTO and obesity due to melanocortin 4 receptor deficiency.