PTPN14 and neoplasm: Consistent with the tumor-suppressive role of these two miRNAs, TGFBR3 was reported to suppress breast cancer progression through TGF-beta signaling (Lee et al., 2010), and RBMS3 and PTPN14 were also shown to play roles in inhibiting metastasis (Belle et al., 2015; Zhu et al., 2019a).