Specifically, potential let-7f binding sites were identified in IL23R mRNA in human memory CD4+ T cells (52), and loss of let-7e- and let-7f-mediated regulation of a human IL23R gene variant was shown to be associated with inflammatory bowel disease, due to a polymorphism in the 3' UTR of IL-23R mRNA sequence (64). Here, IL23R is linked to inflammatory bowel disease.