On the other hand, Cox et al. (38) showed a downregulation of let-7d, f, i, and, together with Martinelli-Boneschi et al. (39), let-7g, in peripheral blood samples of MS patients, whereas, Guan et al. (37) reported a decrease in let-7g and let-7i in pathogenic CD4+ T cells in EAE, but at the same time let-7b, c, d, f and especially let-7e, were upregulated. This evidence concerns the gene CD4 and myeloid sarcoma.