C5 and preeclampsia: Whereby immune complexes and necrotic cells are not appropriate lysed in preeclamptic placentas (28) Lim et al. did not find any differences in C5a receptor (C5aR) in contrast to Ma et al. (28, 31) They detected an elevated C5aR expression at trophoblast cells of preeclamptic placentas and suggested that the placental C5a/C5aR pathway supported to the development of preeclampsia by regulating placental trophoblasts dysfunction (31).