Importantly, the IL-17A receptor is ubiquitously expressed in the vessel wall; among the pleiotropic activities of this receptor the induction of the production of TNF-α, IL-1β, CCL2, and adhesion molecules like intercellular adhesion molecule 1 (ICAM-1) provide important links to the pathogenesis of atherosclerosis (98). The gene discussed is ICAM1; the disease is atherosclerosis.