From a functional standpoint, IL-17A was also shown to promote endothelial dysfunction and angiotensin II-induced hypertension in a recent publication: in this murine model, angiotensin II infusion increased IL-17 production from T cells, and IL-17 knockout mice did not develop sustained hypertension, endothelial dysfunction, or evidence of vascular oxidative stress after chronic infusion of this potent vasoconstrictor (114). This evidence concerns the gene IL17A and Hypertension.