AGT and Hypertension: From a functional standpoint, IL-17A was also shown to promote endothelial dysfunction and angiotensin II-induced hypertension in a recent publication: in this murine model, angiotensin II infusion increased IL-17 production from T cells, and IL-17 knockout mice did not develop sustained hypertension, endothelial dysfunction, or evidence of vascular oxidative stress after chronic infusion of this potent vasoconstrictor (114).