Consistent with these findings, our results showed that metastatic Stat4−/− tumor mice displayed markedly large populations of CD11b+Ly6GhiLy6Cint and CD11b+Ly6G−Ly6Chi cells, representative of granulocytic and monocytic MDSCs respectively, in their lymph nodes and spleens, compared to WT. Here, STAT4 is linked to neoplasm.