CD11b+Ly6G+Ly6Cint and CD11b+Ly6ChiLy6G− myeloid cell populations, referred to as granulocytic and monocytic myeloid derived suppressor cells (G-MDSCs and M-MDSCs, respectively) are known to promote metastasis in HNSCC. Here, ITGAM is linked to head and neck squamous cell carcinoma.