This all is in line with the fact that fully developed eLFs with FDCs, compartmentation into a light and dark zone, an excess of GC-B cells over TFHs as well as the presence of “true”, i.e., active CD4+CXCR5+BCL-6+ TFHs are rare in human autoimmune diseases (64). The gene discussed is BCL6; the disease is autoimmune disease.