ICOS and colorectal carcinoma: These intestinal ILC3 express higher levels of the activating receptors ICOS and CD69 (59, 60), regulators of tumor responses CD244 and CD39 (59), and exhibit enhanced production of the downstream signaling cytokines IL-17 and IL-22 that contribute to the pathogenesis of CRC (96) (Table 3 and Figure 1C).