Although this finding contradicts our original hypothesis of immune-activated IDO upregulation, it is in line with results from two recent amino-acid profiling studies (one cross-sectional study in 208 first episode psychosis patients and one 7-month follow-up study in 38 schizophrenia patients) in which tryptophan and kynurenine were decreased in participants with schizophrenia vs. controls (26, 27). Here, IDO1 is linked to psychotic disorder.