IL15 and soft tissue sarcoma: These include the use of viral vectored cytokine delivery approaches (brain cancer), systemic administration of IL-12 nanoparticles (soft tissue sarcoma), bacterial delivered therapeutics (e.g., engineered hypoxia targeting Salmonella in soft tissue sarcoma), regulatory T cell depletion with metronomically delivered chemotherapeutics (e.g., toceranib), adoptive transfer of non-specifically activated T cells and IL-15 activated NK cells (osteosarcoma), along with a variety of different cancer vaccines (50, 55, 67).