Although liraglutide is the only GLP-1 receptor agonist that is currently FDA approved as an anti-obesity medication, this review will cover the CV risks and benefits of multiple GLP-1 receptor agonists, including liraglutide, semaglutide, exenatide, dulaglutide, and lixisenatide. The gene discussed is GLP1R; the disease is obesity due to melanocortin 4 receptor deficiency.