It has been found that NHE1 activation by growth factors like neurotensin and its analogs was accompanied by phosphorylation of serine residues of the exchanger, leading to locally acidic extracellular conditions favoring tumor cell invasion at a very early stage of tumor development (Olszewski and Hamilton, 2009; Olszewski et al., 2010). Here, SLC9A1 is linked to neoplasm.