SLC9A1 and neoplasm: At the same time, NHE1 favors formation of invadopodial structures (Cardone et al., 2015) required for invasion which is consistent with the general idea that an acidic extracellular pH promotes tumor invasion by stimulation of protease secretion and induction of proinvasive mediators, and also by suppression of apoptosis through intracellular alkalinization (Lagadic-Gossmann et al., 2004; Cardone et al., 2005).