NHE1 interacts with proteins of the ezrin, radixin, moesin (ERM) family (Denker et al., 2000) and also with CD44 (Bourguignon et al., 2004), an adhesion molecule which (i) is also known to interact with ERM proteins, (ii) is ubiquitously expressed in cancer cells and (iii) regulates cell adhesion and motility (Goodison et al., 1999; Yonemura et al., 1999). The gene discussed is SLC9A1; the disease is cancer.