However, diabetes increased SOD-1 expression in arteries from WT diabetic mice (AU, T1D = 1.4 ± 0.1 vs. control = 1.0 ± 0.1; P < 0.05), which was not observed in arteries from Nlrp3–/– mice (Figure 3C). Here, NLRP3 is linked to type 1 diabetes mellitus.