NOX4 and type 1 diabetes mellitus: In addition, Nlrp3–/– mice exhibited reduced vascular Nox4 expression when compared to their respective counterpart C57BL/6 mice (AU, Nlrp3–/– = 0.7 ± 0.1 vs. control = 1.1 ± 0.1; Nlrp3–/– T1D = 0.7 ± 0.2 vs. T1D = 0.9 ± 0.1; P < 0.05) (Figure 3D).