NLRP3 and type 1 diabetes mellitus: NLRP3 deficiency prevented diabetes-induced decreased endothelium-dependent relaxation in mesenteric arteries (pD2, Nlrp3–/– T1D = 6.6 ± 0.1 vs. T1D = 6.2 ± 0.2; Rmax, Nlrp3–/– T1D = 80.8 ± 3.3 vs. T1D = 47.2 ± 4.9; P < 0.05) (Figure 2A).