In addition, diabetes significantly increased superoxide anion generation (AU, T1D = 2.1 ± 0.4 vs. control = 1.0 ± 0.1; P < 0.05) (Figure 2E) as well as hydrogen peroxide generation (AU, T1D = 2.0 ± 0.4 vs. control = 1.0 ± 0.1; P < 0.05) (Figure 2F) in mesenteric arteries from C57BL/6 mice, which was not observed in mesenteric arteries from diabetic Nlrp3–/– mice. Here, NLRP3 is linked to diabetes mellitus.