Reduced vasodilation in WT diabetic mice was partially reverted by MCC950, a selective NLRP3 inhibitor (pD2, T1D+MCC950 = 6.9 ± 0.2 vs. T1D = 6.2 ± 0.2; Rmax, T1D+MCC950 = 62.5 ± 3.8 vs. T1D = 46.6 ± 4.1; P < 0.05) (Figure 2B), and completely reverted by the superoxide anion scavenger Tiron (pD2, T1D+Tiron = 6.6 ± 0.1 vs. T1D = 6.2 ± 0.2; Rmax, T1D+Tiron = 78.4 ± 3.1 vs. T1D = 46.6 ± 4.1; P < 0.05) (Figure 2C) and by peg-catalase (pD2, T1D+Peg-catalase = 6.4 ± 0.1 vs. T1D = 6.2 ± 0.2; Rmax, T1D+Peg-catalase = 86.4 ± 2.8 vs. T1D = 46.6 ± 4.1; P < 0.05) (Figure 2D). This evidence concerns the gene NLRP3 and type 1 diabetes mellitus.