CPVT is a heterogeneous genetic disease, including autosomal dominant mutations in ryanodine receptor type 2 (RyR2, CPVT1), autosomal recessive mutations in calsequestrin 2 (CASQ2, CPVT2), and more rarely mutations in triadin or calmodulin. The gene discussed is CASQ2; the disease is catecholaminergic polymorphic ventricular tachycardia.