In vivo telemetric electrocardiograms (ECG) measurements showed that treatment with the SK4 channel blockers, TRAM-34 and clotrimazole, triggered sinus bradycardia and greatly reduced the ventricular arrhythmias of CASQ2-D307H KI and CASQ2 knockout mice at rest and following exercise (Haron-Khun et al., 2017). Here, CASQ2 is linked to Sinus bradycardia.