CASQ2 and Ventricular arrhythmia: In contrast, 9 out of 12 TRAM-34-treated (20 mg/kg) CASQ2-D307H KI mice exhibited normal sinus rhythm at rest, while following treadmill exercise, 4 out of 12 animals remained with normal sinus rhythm without significant ventricular arrhythmia (Figures 3E, F and Figures 4E, F and Table 1).