Moreover, GH alleviated DSS-induced colitis in mice by alleviating weight loss, stool consistency change, hematochezia, colon shortening, IL-6, TNF-α, iNOS, and COX-2 expression, activation of NF-κB and MAPK pathways, and the phosphorylation of AMPKα and PRAS40 in colon tissues, as well as colonic damage and infiltration of macrophages in colon of mice with DSS-induced colitis. Here, AKT1S1 is linked to colitis.