Our findings showed that GH led to an amelioration of symptoms of weight loss, blood in stool, diarrhea, and colon shortening, inflammatory mediators IL-6, TNF-α, iNOS, and COX-2 expression, the activation of NF-κB and MAPK pathways, AMPKα and PRAS40 phosphorylation, histopathological damage, and infiltration of macrophages in the colon of mice with DSS-induced colitis. Here, PTGS2 is linked to colitis.